Protein Details: Aquaporin PIP2-1

Protein ID

ICDB_Pro_0529

Protein Name

Aquaporin PIP2-1

Gene Name

PIP2-1; PIP2A; At3g53420; F4P12.120

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

287 amino acids

AlphaFoldDB

AF-P43286-F1-model_v4.pdb

Function

Water channel required to facilitate the transport of water across cell membrane. Probably involved in root water uptake. Its function is impaired by Hg(2+).

Sequence

MAKDVEAVPGEGFQTRDYQDPPPAPFIDGAELKKWSFYRAVIAEFVATLLFLYITVLTVIGYKIQSDTDAGGVDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATDPKRSARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKPWDDHWIFWVGPFIGAAIAAFYHQFVLRASGSKSLGSFRSAANV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Predominantly expressed in roots and green siliques; Also expressed at lower level above ground and in flower buds.

DOI ID

10.1046/j.1365-313x.1994.6020187.x; 10.1038/35048706; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1105/tpc.008888; 10.1073/pnas.97.7.3718; 10.1186/gb-2001-3-1-research0001; 10.1074/mcp.m400001-mcp200; 10.1042/bj20060569; 10.1074/mcp.m700566-mcp200; 10.1105/tpc.108.061994

RefSeq

NP_001030851.1; NP_190910.1